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Two women and a man died in the fiery crash near milepost 45.2 on the eastbound side around 1:45 a.m., the Morris County Prosecutor's Office said.
A young man hospitalized in the crash suffered severe burns, a responder said.
The crash may have been caused by a wrong-way driver, according to CBS News.
Their identities of the victims were not released.
One car was engulfed in flames and at least two others seemed to have been involved, news reports say.
A Fed-Ex truck may have also been involved, according to reports.
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